The UCSF Benioff Children's Hospital opened on February 1st, 2015 as the only stand-alone children's hospital in San Francisco. The hospital provides care for children from throughout the San Francisco Bay Area, as well as tertiary referrals from throughout Northern California and the western United States. Family friendly rooms with highly integrated technology, imaging suites with surround sound and projected images to reduce patient anxiety, and a K-12 accredited school within the hospital are unique features designed to help children continue as much of a normal life as possible during hospitalization. UCSF Benioff Children's Hospital is one of three new hospitals which make up the UCSF Medical Center at Mission Bay, which also includes the Bakar Cancer Hospital and Betty Irene Moore Women's Hospital. This campus is located in the beautiful and sunny Mission Bay neighborhood with close proximity to downtown San Francisco and the Mission District, and with abundant new affordable housing within a few blocks.

Child neurology fellows rotate on several inpatient services at this hospital during their R4 and R5 years. The child neurology Hospitalist Service acts as the consulting service for children and adolescents with neurological disease, and is run by the child neurology fellow working with rotating adult neurology residents. The Neurological Intensive Care Nursery (NICN) treats infants with primary and secondary neurological disorders. UCSF is the birthplace of neurological intensive care in neonates, and here child neurology fellows and adult neurology residents in their R3 year learn how to manage conditions including stroke, hypoxic-ischemic encephalopathy, neonatal seizures and genetic disorders. Fellows rotating on the Epilepsy Monitoring Unit care for patients admitted for continuous video EEG monitoring to characterize seizure type and localization of epileptogenic foci as preparation for epilepsy surgery.